Berberine Supplement

Activates adenosine mono-phosphate kinase (AMPK) which helps improve metabolism, supports cardiovascular health, and stabilizes mitochondria

Clinical Applications

• Aids in Maintaining a Healthy Metabolism (can assist with weight loss)
• Balances Blood Sugar (can assist with insulin resistance, pre-diabetes, and diabetes)
• Supports CV Health & Heart Function (can assist with hypertension)
• Enhances Cell Signaling for Efficient ATP Production (can assist with fatigue)
• Maintains Healthy Cholesterol Levels (can assist with hyperlipidemia or hypertriglyceridemia)

Recent studies show that nearly half of adults in the United States (47%, or 116 million) have hypertension, and 93% of Americans are metabolically unhealthy, mostly due to insulin resistance. Berberine Plus provides a powerful formula for those seeking to optimize multiple mechanisms of cardiovascular and metabolic health. It is a formula backed by extensive clinical research, that is designed to address several factors associated with ideal cardiometabolic health. The powerful combination of berberine and alpha lipoic acid (ALA) helps maintain heart function, metabolism, antioxidant status, lipid, and glucose levels. Berberine and alpha lipoic acid activate the master metabolic switch, adenosine mono-phosphate kinase (AMPK). Activation of this metabolic enzyme triggers a variety of genes that help improve metabolism by increasing fatty acid oxidation, up taking glucose, enhancing insulin sensitivity, and decreasing body weight in addition to stabilizing mitochondria.3,4

Berberine

• Maintains blood pressure
• Supports heart rhythm and contraction
• Supports healthy cholesterol levels
• Maintains healthy blood glucose levels by:

• activating AMPK -> energy production, improved insulin sensitivity, & fat burning
• Promotes the uptake of glucose through a mechanism that does not require insulin -> better glucose usage within the cell

Berberine is a plant extract that has been used in Chinese medicine for over 2,500 years for its broad range of health-promoting properties. A clinical trial with 32 subjects demonstrated that administration of 500 mg of berberine given twice daily for three months helped maintain healthy LDL cholesterol and triglyceride levels, versus the control group.7 In addition to maintaining healthy lipid levels, berberine has also been shown to maintain healthy blood glucose levels through activation of AMPK.9 AMPK causes long and short-term metabolic changes, leading to an improvement in energy production and a reduction of energy storage. AMPK improves insulin sensitivity, and down-regulates genes involved in fat storage while activating genes involved with burning fat.3Activation of AMPK has been shown to stimulate the transcription factor involved in replicating mitochondria for increased metabolic potential.10Berberine has also been shown to promote the uptake of glucose through a mechanism that does not require insulin, promoting better glucose usage within the cell.11 A study found that berberine improved glucose tolerance and maintained balanced insulin levels, while helping to maintain healthy total cholesterol and triglyceride levels after four weeks of berberine administration.12

Alpha lipoic acid (ALA)

• Maintains healthy blood vessel and circulatory health
• Supports healthy cholesterol levels
• Improves oxidative stress & reduces free radical damage (antioxidant)
• Maintains healthy blood glucose levels by:

• activating AMPK -> energy production, improved insulin sensitivity, & fat burning
• breaks down carbohydrates & fatty acids
• enhances glucose transport & utilization

ALA is a nutrient required for cellular metabolism, specifically the breakdown of carbohydrates and fatty acids.13 ALA has been shown to support blood sugar balance by activating AMPK, a major regulator of cellular energy.14 A study using a dose of 600 mg/day of ALA over three months demonstrated that ALA helps support healthy lipid levels while improving oxidative stress (reducing free radical damage) by 38%.15 An additional study examining the effects of ALA on 74 subjects found that within the four-week, placebo-controlled trial, administration of 600 mg of ALA per day significantly enhanced glucose transport and utilization.16 ALA is also a potent antioxidant. It scavenges free radicals while aiding in the regeneration of the body’s antioxidants including vitamin C, vitamin E and glutathione.17 ALA also helps maintain healthy blood vessel and circulatory health through its antioxidant-boosting mechanisms.

Suggested Use: 3 capsules per day or as recommended by your health care professional.